Dosage-sensitive X-linked locus in ̄uences the development of amygdala and orbitofrontal cortex, and fear recognition in humans
نویسندگان
چکیده
1Wellcome Department of Imaging Neuroscience, Institute of Neurology, 2Behavioural and Brain Sciences Unit, Institute of Child Health, London, 3Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, UK, 4Department of Neuroscience, Section of Pharmacology, BMC, Uppsala, Sweden and 5Instituto Santa Lucia, Rome, Italy Correspondence to: David Skuse, Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. E-mail: [email protected]
منابع مشابه
Dosage-sensitive X-linked locus influences the development of amygdala and orbitofrontal cortex, and fear recognition in humans.
The amygdala, which plays a critical role in emotional learning and social cognition, is structurally and functionally sexually dimorphic in humans. We used magnetic neuroimaging and molecular genetic analyses with healthy subjects and patients possessing X-chromosome anomalies to find dosage-sensitive genes that might influence amygdala development. If such X-linked genes lacked a homologue on...
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